Tags: galactose animal lactose d-galactose D-Galactopyranose

What is D-Galactose

D-Galactose is an aldohexose that occurs naturally in the body, It is commonly found in dairy products, sugar beets, certain gums and mucilages. 


D-Galacose is a basic ingredient usually used for creating brain senescence in animal models, increasing glycoproteins production through adding to cell culture medium.  As one of primary monosaccharides, D-Galactose can be acted as a basic start material for synthesis of many important intermediates. Certain medications contain galactose as excipient.

Animal derived D-galactose is hydrolyzed from lactose which is seperated from milk. It's the typical & common production method to producing galactose.  Animal derived D-galactose is widely use in lots of laboratories and industrial enterprises.

 

Properties

CAS No: 59-23-4
EINECS: 200-416-4
Alias Name: Glactose;  D-Galactopyranose; α-D-Galactopyranose; alpha-D-Galactopyranose;D-(+)-Galactose
Chemical Structure:
Molecular Formula: C6H12O6
Molecular Weight: 180.16
Assay: NLT 99.0%
Solubility: Easily soluble in water
Specific Rotation: +78.0º to +81.5º
Application:

Targeted drug development
Biochemical reagent
Ingredient for cell culture medium
Start material for synthesis
Excipient

 

Applicaion

Ingredient for Cell Culture Medium

The terminal sialic acid component of a glycoprotein oligosaccharide side chain is known to have an effect on numerous aspects and properties of a glycoprotein, including absorption, solubility, thermal stability, serum half life, clearance from the serum, as well as its physical and chemical structure/behavior and its immunogenicity.

The sialic content of the produced glycoproteins is increased and enhanced when D-galactose is added to feed medium. If D-galactose is supplied daily to the cells during the entire culture period,  it will increasing the quality of the final glycoprotein product. 

Developing  Targeted Drugs

Asialoglycoprotein receptor (ASGPR) was specifically expressed by hepatocytes, which could recognize and bind asialoglycoprotein, galactose (Gal), galactosamine, N-acetylgalactosamine (GalNAc), etc. with high affinity. 

Targeted delivery of modified lipoprotein particles, genes, chemically modified oligonucleotides, nucleoside analogue (eg. Ribavirin), small molecule compounds(eg. Doxorubicin), siRNA, and microRNA antagonists to hepatocytes through this mechanism are under developing.

Start material for synthesis

D-Galctose is a basic bone acting as the start material for many kinds of pharmaceutical and biochemical intermediate, such as Diacetone-D-galactose (1,2:3,4-Di-O-Isopropylidene-α-D-Galactopyranose) , beta-D-Galactose pentaacetate, methyl-D-galactopyranoside.

 

Yixin's advantages

Competitive price and good quality

Based on experienes in long term production and research of D-galactose, Yixin could offer more competitive price with a good product quality together.  Yixin's D-Galactose can meet USP/EP standard.

 

GMP  system

Yixin plant derived D-galactose is produced under GMP system to ensure the traceability and consistent supply. Yixin GMP system was  established and improved over  20 years,  for carbohydrates facility,  NSF GMP certificate has been obtained since 2015, In 2015 Yixin carbohydrate facility was inspected  and concluded by US FDA to meet the related requirements.

-In 2015-2018 Yixin Carbohydrates facility was assessed by NSF international and found to be in compliance with GMP Requirements in NSF/ANSI Standard173,Section B Dietary Supplements.

-Yixin Carbohydrates Facility was inspected in 2015 by US.FDA, it’s concluded to meet the related requirement of Dietary Supplement Ingredient.

-In 2015-2018 Yixin Carbohydrates facility were certificated by 3rd Kosher certification organization.

-Since 2002, Yixin has obtained the Certificates of GMP from CFDA for 9 dosage forms successively including capsules, tablets, syrup, preparation for external use and  etc. In 2006 and 2011 Yixin facility of API was inspected and classified as acceptable by US FDA.